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Archival plate of Eupatorium perfoliatum, from Bigelow, American Medical Botany, 1817 to 1820
The Moss Herbal Database
Eupatorium perfoliatum
Fam. Asteraceae
Parts: Leaves and flowers
Plate: Bigelow, American Medical Botany, 1817 to 1820 ↗

Boneset

Eupatorium perfoliatum
Also: Feverwort, Thoroughwort, Ague weed
WarmingDryingRelaxing

Breaks a flu fever and eases the deep ache in the bones.

A wetland perennial whose paired leaves fuse around the stem, so the stalk seems to pierce a single leaf, topped in late summer with flat clusters of fuzzy white flowers. Boneset is intensely bitter; taken hot, it opens the skin to release a fever and loosens the aching muscles of flu.

Energetics
Warming, drying, relaxing
Taste
Intensely bitter, pungent
Family
Asteraceae (daisy family)
Parts used
Leaves and flowers

Medicinal uses 4

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Traditional useLab and mechanism studiesClinical studies
  • The classic remedy for flu that settles deep in the bones with chills and aching; a lab study found it blocked influenza A from attaching to cells.

  • Sipped hot, relaxes the skin and muscles so the heat of a fever can break in a sweat.

  • Eases the deep muscle and bone aches that come with fever.

  • Taken cool in small sips before meals, a strong bitter tonic for a poor appetite and a slow liver.

Preparations

Small, frequent doses of hot infusion or tincture for fevers, and hot flu blends.

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Cautions

  • Large doses cause nausea and vomiting, and a whole cup of the hot tea can bring on nausea. Keep to small, frequent doses.
  • It carries trace pyrrolizidine alkaloids, which strain the liver over time; use it for days during an acute illness, not as a daily tonic.
  • People allergic to ragweed, chamomile, or other daisy-family plants may react to it.
  • Flu with trouble breathing, chest pain, confusion, or a fever over 103°F needs medical care.

Medication interactions

Practitioner Practitioners are able to see the 2 types of medicine flagged for boneset, each with the mechanism and what to do. The plain-language cautions above stay open to everyone.

Pregnancy & breastfeeding

PregnancyAvoid

Boneset carries trace pyrrolizidine alkaloids, compounds that can harm the liver, so it stays out of pregnancy.

BreastfeedingAvoid

The same trace alkaloids could reach a nursing baby, so it waits until after weaning.

Practitioner Practitioners are able to see the full entry from the Moss Herbalism Pregnancy Safety Database: trimester ratings, uterine and placental action, breastfeeding and nursing-baby effects, chemistry, traditional use, studies, and sources.

Folklore

Perfoliatum means through the leaf, for the stem that runs through each fused pair of leaves, and by the doctrine of signatures that joined leaf promised to knit broken bones. Others trace the name to breakbone fever, an old name for dengue, whose aches it eased. The Haudenosaunee and other Native nations of the East gave it for fevers, and through the nineteenth century bundles of it hung drying in farmhouse attics, ready for winter.

How to grow

A native perennial for full sun and moist to wet soil, three to five feet tall. Sow seed in fall, or chill it for a month before sowing in spring. The late-summer flowers draw bees, wasps, and butterflies. Cut the tops just as the flowers open.

In the wild

Wet meadows, marshes, ditches, and stream banks across eastern and central North America, from Nova Scotia and Quebec west to the Dakotas and south to Florida and Texas.

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